Nephrosis, congenital
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We have previously mapped the gene for congenital nephrotic syndrome (CNF) to the APLP1 region, to the vicinity of marker D19S610 located between markers D19S191 and DS19608.
|
9521588 |
1998 |
Carcinoid Tumor
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
We conclude that APLP1 is differentially upregulated in gastrointestinal NE tumours and that APLP1 may be important for the dissemination of small intestinal carcinoids.
|
18430897 |
2008 |
Alzheimer's Disease
|
0.080 |
Biomarker
|
disease |
BEFREE |
The amyloid precursor-like protein-1 (APLP1) is a member of a protein family that includes the Alzheimer's disease-associated amyloid precursor protein (APP).
|
19401174 |
2009 |
Alzheimer's Disease
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
Taken together, the direct cleavage of APLP1 is a novel feature of the γ-secretase prompting a re-thinking of γ-secretase activity modulation as a therapeutic strategy for Alzheimer disease.
|
29382944 |
2018 |
Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Quantitative real-time PCR and western blot analysis demonstrated higher expression of APLP1 in carcinoid metastases relative to primary tumours indicating a role of APLP1 in tumour dissemination.
|
18430897 |
2008 |
Neoplasm Metastasis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Quantitative real-time PCR and western blot analysis demonstrated higher expression of APLP1 in carcinoid metastases relative to primary tumours indicating a role of APLP1 in tumour dissemination.
|
18430897 |
2008 |
Secondary Neoplasm
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Quantitative real-time PCR and western blot analysis demonstrated higher expression of APLP1 in carcinoid metastases relative to primary tumours indicating a role of APLP1 in tumour dissemination.
|
18430897 |
2008 |
Alzheimer's Disease
|
0.080 |
Biomarker
|
disease |
BEFREE |
Presence of a "CAGA box" in the APP gene unique to amyloid plaque-forming species and absent in all APLP-1/2 genes: implications in Alzheimer's disease.
|
15208260 |
2004 |
Alzheimer's Disease
|
0.080 |
Biomarker
|
disease |
BEFREE |
Our results suggest that even though APLP1 and APLP2 cannot generate Abeta, they may potentially contribute to the pathology of AD by generating peptide fragments whose toxicity is comparable to that of APPC31.
|
12124429 |
2002 |
Influenza due to Influenza A virus subtype H1N1
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
No Major Host Genetic Risk Factor Contributed to A(H1N1)2009 Influenza Severity.
|
26379185 |
2015 |
Epilepsy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Moreover, pilocarpine induced a significant down-regulation of APLP1 mRNA expression at 6 h after epilepsy initiation (P< 0.05), and at 30 h, this down-regulation became more dramatic (P< 0.01), which lasted till day 15 (P< 0.01).
|
19448684 |
2009 |
Mild cognitive disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Methods APLP1 and NPTXR concentrations were measured in the CSF of patients with mild cognitive impairment (MCI) (n = 14), mild AD (n = 21), moderate AD (n = 43) and severe AD (n = 30) using enzyme-linked immunosorbent assays (ELISAs).
|
31415236 |
2019 |
Neuroblastoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Increased gene expression of beta-amyloid precursor protein and its homologues APLP1 and APLP2 in human neuroblastoma cells in response to retinoic acid.
|
9121703 |
1997 |
Central neuroblastoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Increased gene expression of beta-amyloid precursor protein and its homologues APLP1 and APLP2 in human neuroblastoma cells in response to retinoic acid.
|
9121703 |
1997 |
Childhood Neuroblastoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Increased gene expression of beta-amyloid precursor protein and its homologues APLP1 and APLP2 in human neuroblastoma cells in response to retinoic acid.
|
9121703 |
1997 |
Alzheimer's Disease
|
0.080 |
Biomarker
|
disease |
BEFREE |
In conclusion, our results establish that APLPs show typical features of SAMs and indicate that increased surface expression, as observed for APLP1, is essential for proper synapse formation <i>in vitro</i> and synapse maintenance <i>in vivo</i><b>SIGNIFICANCE STATEMENT</b> According to the amyloid-cascade hypothesis, Alzheimer's disease is caused by the accumulation of Aβ peptides derived from sequential cleavage of the amyloid precursor protein (APP) by β-site APP cleaving enzyme 1 (BACE1) and γ-secretase.
|
28450540 |
2017 |
Alzheimer's Disease
|
0.080 |
Biomarker
|
disease |
BEFREE |
CSF APLP1 was not different between any of the AD severity groups (p = 0.31).
|
31415236 |
2019 |
Alzheimer's Disease
|
0.080 |
Biomarker
|
disease |
BEFREE |
Consistently, knockdown or antagonization of DOR reduces secretase activities and ameliorates Abeta pathology and Abeta-dependent behavioral deficits, but does not affect the processing of Notch, N-cadherin or APLP in AD model mice.
|
20066010 |
2010 |
Familial Alzheimer Disease (FAD)
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Clues to the function of APP derive from the recent finding that it is a member of a highly conserved protein family that includes the mammalian amyloid precursor-like protein (APLP1) gene which maps to the same general region of human chromosome 19 linked to late-onset FAD.
|
8220435 |
1993 |
Finnish congenital nephrotic syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Because of its location and the proposed interference of amyloid with basement membrane assembly, APLP1 has been considered a candidate gene for CNF.
|
9521588 |
1998 |
Amyloidosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Because of its location and the proposed interference of amyloid with basement membrane assembly, APLP1 has been considered a candidate gene for CNF.
|
9521588 |
1998 |
Neurodegenerative Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Based on these data, a mechanism is proposed whereby p53-dependent induction of APLP1 is involved in neural cell death, and which may exacerbate neuronal cell loss in some acute or chronic neurodegenerative disorders.
|
17533371 |
2007 |
Neuroblastoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Amyloid-beta precursor-like protein APLP1 is a novel p53 transcriptional target gene that augments neuroblastoma cell death upon genotoxic stress.
|
17533371 |
2007 |
Central neuroblastoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Amyloid-beta precursor-like protein APLP1 is a novel p53 transcriptional target gene that augments neuroblastoma cell death upon genotoxic stress.
|
17533371 |
2007 |
Childhood Neuroblastoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Amyloid-beta precursor-like protein APLP1 is a novel p53 transcriptional target gene that augments neuroblastoma cell death upon genotoxic stress.
|
17533371 |
2007 |